Article
Recurrent astrocytoma in a child: a report of cytogenetics and TP53 gene mutation screening.
Neuro-oncology - 1 Jul 2000
Dam A, Fock J M, Hayes V M, Molenaar W M, van den Berg E
Abstract excerpt
An 8-year-old girl presented with a cerebral tumor and 3 recurrences within 15 months. The primary tumor was a low-grade astrocytoma, but the recurrences showed progressively malignant phenotypes with increasing mitotic activity and MIB-1 labeling indices. Radiotherapy was given between the first and the second recurrences. Cytogenetic analysis of the first and the second recurrences showed abnormal karyotypes....
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