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Article

Primary Astrocytic Tumours and Paired Recurrences have Similar Biological Features in IDH1, TP53 and TERTp Mutation and MGMT, ATRX Loss.

Scientific reports - 12 Oct 2017

Li Xia, Wei Jie, Liu Yixiong, Li Peifeng, Fan Linni, Wang Yingmei, Li Mingyang, Zhao Danhui, Yu Zhou, Ye Jing, Guo Ying, Yan Qingguo, Guo Shuangping, Wang Zhe

Abstract excerpt

Astrocytic tumours are the most common type of primary malignant brain tumour. Most astrocytic tumours will recur at some point after surgery. Currently, the combination of radiotherapy and chemotherapy does not prevent the recurrence of astrocytic tumours. In this study, we investigated the consistency in isocitrate dehydrogenase 1 (IDH1), tumour protein p53 (TP53) and telomerase reverse transcriptase promoter...

Topics

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Astrocytoma
DNA Modification Methylases
DNA Repair Enzymes
Isocitrate Dehydrogenase
Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Progression-Free Survival

X-linked Nuclear Protein

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Identifiers

PMID: 29026176
DOI: 10.1038/s41598-017-13272-9
PMCID: PMC5638900

Genes

IDH1
MGMT
ATRX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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