Article
Concurrent EGFR amplification and TP-53 mutation in glioblastomas.
Clinical neuropathology - 1 Jan 2000
Gil-Benso R, Lopez-Gines C, Benito R, López-Guerrero J A, Callaghan R C, Pellín A, Roldán P, Cerdá-Nicolas M
Abstract excerpt
Glioblastoma multiforme is the most common and most aggressive of the primary brain tumors. The mean survival of patients is 10-12 months. Conventional therapy of surgery, radiation and chemotherapy is largely palliative. Cytogenetically, karyotypes of glioblastomas are very complex with trisomy 7 and monosomy 10 as the most frequent abnormalities. A genetic alteration that is significantly more frequent in...
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