Timing and role of p53 gene mutation in the recurrence of glioma.

doi:10.1016/s0006-291x(05)81186-6

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Article

Timing and role of p53 gene mutation in the recurrence of glioma.

Biochemical and biophysical research communications - 31 Oct 1991

Hayashi Y, Yamashita J, Yamaguchi K

Abstract excerpt

Recently a 17p deletion and p53 gene mutations were reported in human gliomas, but the relationship of the timing of p53 gene mutation and oncogenesis of glioma is still obscure. We examined eight pairs of primary and recurrent gliomas. Four of eight had a histological malignant transformation. I...

Topics

Base Sequence
Chromosome Deletion
DNA, Neoplasm
Genes, p53
Glioma
Humans
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Oligonucleotides, Antisense
Polymerase Chain Reaction
Polymorphism, Genetic
Recurrence

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