Article
Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.
Neuro-oncology - 1 Apr 1999
Nozaki M, Tada M, Kobayashi H, Zhang C L, Sawamura Y, Abe H, Ishii N, Van Meir E G
Abstract excerpt
Loss of function of the p53 tumor suppressor gene due to mutation occurs early in astrocytoma tumorigenesis in about 30-40% of cases. This is believed to confer a growth advantage to the cells, allowing them to clonally expand due to loss of the p53-controlled G1 checkpoint and apoptosis. Genetic instability due to the impaired ability of p53 to mediate DNA damage repair further facilitates the acquisition of new...
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