Article
Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression.
Journal of neuropathology and experimental neurology - 1 Jul 1996
Reifenberger J, Ring G U, Gies U, Cobbers L, Oberstrass J, An H X, Niederacher D, Wechsler W, Reifenberger G
Abstract excerpt
Genomic alterations and expression of the p53 tumor suppressor gene and the epidermal factor receptor gene (EGFR) were investigated in 22 patients with primary World Health Organization (WHO) grade II gliomas that on recurrence had progressed to malignant gliomas of WHO grades III or IV. Mutation...
Topics
- Adult
- Base Sequence
- Brain Neoplasms
- Disease Progression
- ErbB Receptors
- Female
- Glioma
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Neoplasm Recurrence, Local