Article
p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression.
Journal of the National Cancer Institute - 6 Jul 1994
van Meyel D J, Ramsay D A, Casson A G, Keeney M, Chambers A F, Cairncross J G
Abstract excerpt
BACKGROUND: Two lines of evidence indirectly implicate the tumor suppressor p53 (also known as TP53) gene in glioma development. First, germline mutations of the p53 gene are associated with increased susceptibility to glioma. Second, chromosome 17p deletions and p53 gene mutations are found freq...
Topics
- Adult
- Aged
- Astrocytoma
- Base Sequence
- DNA, Neoplasm
- Female
- Flow Cytometry
- Genes, p53
- Humans
- Immunochemistry
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Ploidies
- Polymerase Chain Reaction
- Survival Analysis
- Tumor Suppressor Protein p53