Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population.

doi:10.1038/sj.gene.6363730

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Article

Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population.

Genes and immunity - 1 Feb 2001

Aithal G P, Day C P, Leathart J, Daly A K, Hudson M

Abstract excerpt

Interleukin-4 (IL-4) is an important cytokine in mucosal immunity and plays a critical role in the development of colitis in T-alpha cell receptor mutant mice. Functionally significant polymorphisms have been described in the genes encoding IL-4 and IL-4 receptor. To examine the role of these pol...

Topics

Base Sequence
Crohn Disease
DNA Primers
Genetic Predisposition to Disease
Humans
Interleukin-4
Polymorphism, Single Nucleotide
Receptors, Interleukin-4
United Kingdom

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