Article
Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans.
Genetics - 1 Aug 2001
Smirnova I, Hamblin M T, McBride C, Beutler B, Di Rienzo A
Abstract excerpt
The Toll-like receptor 4 protein acts as the transducing subunit of the lipopolysaccharide receptor complex and assists in the detection of Gram-negative pathogens within the mammalian host. Several lines of evidence support the view that variation at the TLR4 locus may alter host susceptibility to Gram-negative infection or the outcome of infection. Here, we surveyed TLR4 sequence variation in the complete...
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