Article
Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis.
Clinical rheumatology - 1 Aug 2016
Ziaee Vahid, Rezaei Arezou, Harsini Sara, Maddah Marzieh, Zoghi Samaneh, Sadr Maryam, Moradinejad Mohammad Hassan, Rezaei Nima
Abstract excerpt
As cytokines, including interleukin-4 (IL-4), seem to have a pivotal role in the pathogenesis of juvenile idiopathic arthritis (JIA), this study is aimed at investigating of association of polymorphisms in IL-4 and IL-4 receptor α (IL-4RA) genes with susceptibility to JIA. A case-control study was conducted on 53 patients with JIA and 139 healthy unrelated controls. Single nucleotide polymorphisms of IL-4 gene at...
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