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Article

Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Aug 2003

Beghé B, Barton S, Rorke S, Peng Q, Sayers I, Gaunt T, Keith T P, Clough J B, Holgate S T, Holloway J W

Abstract excerpt

BACKGROUND: IL-4 by binding to its receptor (IL-4R) is essential for the development of airway inflammation present in asthma, through the induction of IgE synthesis in B cells and differentiation of T cells to a Th2 phenotype. OBJECTIVE: To investigate the role of four common polymorphisms in th...

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Source

Identifiers

PMID: 12911786
DOI: 10.1046/j.1365-2222.2003.01731.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12911786-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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