Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-4 receptor mutations.

Current opinion in immunology - 1 Dec 1999

Pan P Y, Rothman P

Abstract excerpt

IL-4 plays an important role in regulating immune responses. Distinct signaling pathways, including those for gene activation and cell differentiation and those for cell proliferation and protection from apoptosis, are initiated from the receptor complex for IL-4 following ligand-receptor engagement. Several advances have been made in our understanding of how distinct functions of IL-4 are mediated. Most of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Receptors, Interleukin-4
Share to Signal Transduction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10631544
DOI: 10.1016/s0952-7915(99)00026-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-4 receptor mutations.PMID 10631544Read ↗

Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation.Semantic proximity Read ↗

A two-step selection approach for the identification of ligand-binding determinants in cytokine receptors.Semantic proximity Read ↗

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor.Semantic proximity Read ↗

Growth and Gene Expression Are Predominantly Controlled by Distinct Regions of the Human IL-4 ReceptorSemantic proximity Read ↗

The Interleukin-7 Receptor Signaling Pathway and Its Perturbation in Immunodeficiency, Autoimmune Disease and Lymphoid Malignancy.Semantic proximity Read ↗

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.Semantic proximity Read ↗

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.Semantic proximity Read ↗

Activating mutations in cytokine receptors: implications for receptor function and role in disease.Semantic proximity Read ↗

Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overview.Semantic proximity Read ↗

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.Semantic proximity Read ↗

Interleukin-4 receptor signaling pathways in asthma pathogenesisSemantic proximity Read ↗

An IL-4R alpha allelic variant, I50, acts as a gain-of-function variant relative to V50 for Stat6, but not Th2 differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.