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Article

Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases.

Genes and immunity - 1 Aug 2001

Klein W, Tromm A, Griga T, Fricke H, Folwaczny C, Hocke M, Eitner K, Marx M, Duerig N, Epplen J T

Abstract excerpt

Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine production from Th1 lymphocytes. Functionally relevant polymorphisms have been described in the interleukin-4 and the interleukin-4 receptor alpha genes. Association of inflammatory bowel diseases with these polymorphisms has been reported...

Topics

Alleles
Genotype
Heterozygote
Humans
Inflammatory Bowel Diseases
Interleukin-4
Polymorphism, Genetic
Receptors, Interleukin-4

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 11528525
DOI: 10.1038/sj.gene.6363779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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