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Article

Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease.

Immunogenetics - 1 Jan 2000

Olavesen M G, Hampe J, Mirza M M, Saiz R, Lewis C M, Bridger S, Teare D, Easton D F, Herrmann T, Scott G, Hirst J, Sanderson J, Hodgson S V, Lee J, MacPherson A, Schreiber S, Lennard-Jones J E, Curran M E, Mathew C G

Abstract excerpt

Genetic linkage analysis in families with multiple cases of inflammatory bowel disease (IBD) has mapped a gene which confers susceptibility to IBD to the pericentromeric region of chromosome 16 (IBD1). The linked region includes the interleukin(IL)-4 receptor gene (IL4R). Since IL-4 regulation and expression are abnormal in IBD, the IL4R gene is thus both a positional and functional candidate for IBD1. We...

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Identifiers

PMID: 10663555
DOI: 10.1007/s002510050001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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