Article
Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2006
Einspahr Janine G, Martinez Maria Elena, Jiang Ruiyun, Hsu Chiu-Hsieh, Rashid Asif, Bhattacharrya Achyut K, Ahnen Dennis J, Jacobs Elizabeth T, Houlihan P Scott, Webb C Renee, Alberts David S, Hamilton Stanley R
Abstract excerpt
In colorectal tumorigenesis, Ki-ras proto-oncogene mutation often occurs early in the adenoma-adenocarcinoma sequence, whereas mutation of the p53 gene is associated with late progression to carcinoma. We evaluated the relationship of demographic and clinicopathologic characteristics to Ki-ras mutation and p53 gene product overexpression in 1,093 baseline sporadic colorectal adenomas from 926 individuals enrolled...
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