Article
Microsatellite instability in a population of sporadic colorectal cancers: correlation between genetic and pathological profiles.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Aug 2002
Luceri C, De Filippo C, Guglielmi F, Caderni G, Messerini L, Biggeri A, Mini E, Tonelli F, Cianchi F, Dolara P
Abstract excerpt
BACKGROUND: Tumours with high-frequency microsatellite instability exhibit unique genotype and phenotype features, whereas the difference between low-frequency microsatellite instability and apparently stable tumours is far from being clear. AIMS: To identify distinctive genetic and pathological characteristics of low-frequency microsatellite instability tumours. METHODS: Microsatellite instability status of 57...
Topics
- Adult
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- Female
- Genes, APC
- Humans
- Loss of Heterozygosity
- Male
- Microsatellite Repeats