Article
Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old.
Diseases of the colon and rectum - 1 Feb 2002
Suh Jae Hee, Lim So-Dug, Kim Jin Cheon, Hong Sook Hee, Kang Gyeong Hoon
Abstract excerpt
PURPOSE: Many studies have demonstrated that sporadic microsatellite instability-positive colorectal cancers share several clinicopathologic features with hereditary nonpolyposis colorectal cancers, including right-sided location, young age of onset, characteristic histomorphologic features, and a good prognosis. The aim of this study was to define distinct clinicopathologic features of sporadic microsatellite...
Topics
- Adult
- Case-Control Studies
- Colon
- Colorectal Neoplasms
- Female
- Genes, APC
- Genes, DCC
- Genes, p53
- Genes, ras
- Genotype
- Humans
- Loss of Heterozygosity
- Male
- Microsatellite Repeats