Article
Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR.
Cancer research - 15 Nov 2001
Anderson G R, Brenner B M, Swede H, Chen N, Henry W M, Conroy J M, Karpenko M J, Issa J P, Bartos J D, Brunelle J K, Jahreis G P, Kahlenberg M S, Basik M, Sait S, Rodriguez-Bigas M A, Nowak N J, Petrelli N J, Shows T B, Stoler D L
Abstract excerpt
We have used genome-wide allelotyping with 348 polymorphic autosomal markers spaced, on average, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colorectal carcinomas. We have compared instability measured by this method with that measured by inter-(simple sequence repeat) PCR and microsatellite instability assays. Instability quantitated by fractional allelic loss rates...
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