Article
A substantial proportion of microsatellite-unstable colon tumors carry TP53 mutations while not showing chromosomal instability.
Genes, chromosomes & cancer - 1 Jun 2005
Westra Jantine L, Boven Ludolf G, van der Vlies Pieter, Faber Hendrika, Sikkema Birgit, Schaapveld Michael, Dijkhuizen Trijnie, Hollema Harry, Buys Charles H C M, Plukker John T M, Kok Klaas, Hofstra Robert M W
Abstract excerpt
Chromosomal instability in colon tumors implies the presence of numerical and structural chromosome aberrations and is further characterized by the absence of microsatellite instability and the occurrence of KRAS and/or TP53 mutations. In a previous screening of 194 colon tumors for both microsatellite instability and TP53 mutation, we found 25 microsatellite-unstable tumors, in 9 (36%) of which, presumed to be...
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