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Mutations in the p53 and Ki-ras genes, microsatellite instability and site of tumor origin in colorectal cancer.

Oncology reports - 1 Sept 2005

Catalano Teresa, Curia Maria Cristina, Aceto Gitana, Verginelli Fabio, Cascinu Stefano, Cama Alessandro, Mariani-Costantini Renato, Teti Diana, Battista Pasquale

Abstract excerpt

Using PCR-SSCP screening and direct sequencing we analyzed a series of 28 colorectal carcinomas for mutations in p53 (exons 5-8) and Ki-ras (codons 12, 13 and 61), and for micro-satellite instability (MSI) at BAT25 and BAT26, supplementing data with the analysis of the IARC colorectal cancer p53 mutation database. Mutations were correlated with the site of tumor origin (proximal or distal to the splenic flexure)....

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PMID: 16077965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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