Article
Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas.
Anticancer research - 1 Jan 2000
Hasegawa Arifumi, Fukushima Toshihiko, Mashiko Miyuki, Nakano Keiichi, Suzuki Satoshi, Endo Yoshiyuki, Ohki Shinji, Hatakeyama Yuichi, Koyama Yoshihisa, Inoue Norio, Takebayashi Yuji, Sekikawa Kouji, Takenoshita Sei-ichi
Abstract excerpt
BACKGROUND: The international guidelines for the evaluation of microsatellite instability (MSI) in colorectal cancer were defined in 1997 by the National Cancer Institute (NCI). Here, the relationship between MSI, cancer-associated genes and their clinicopathological variables were revaluated using these guidelines. PATIENTS AND METHODS: Mutations of K-ras at exon 1 and p53 at exons 5, 6, 7 and 8 were analyzed in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.