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Article

Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.

Cancer research - 15 Nov 2007

Santiago Cariluz, Pagán Beatriz, Isidro Angel A, Appleyard Caroline B

Abstract excerpt

Inflammatory bowel disease (IBD) is a gastrointestinal disorder of unknown etiology or cure. One complication of IBD is an increased risk for development of colon cancer. The aims of this study were to use a previously established rat model of colitis to develop a new model of colitis-associated colon cancer and ascertain the involvement of three cancer-related genes: K-ras, adenomatous polyposis coli (APC), and...

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Source

Identifiers

PMID: 18006820
DOI: 10.1158/0008-5472.CAN-07-1418

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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