Article
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
International journal of cancer - 1 Jan 2008
Femia Angelo Pietro, Tarquini Elena, Salvadori Maddalena, Ferri Stefania, Giannini Augusto, Dolara Piero, Caderni Giovanna
Abstract excerpt
K-ras and mucin profile variations, associated with intestinal carcinogenesis, were studied in the preneoplastic lesions, mucin-depleted foci (MDF) and aberrant crypt foci (ACF), and in colonic tumors induced in rats by 1,2-dimethylhydrazine (DMH). The frequency of lesions with K-ras mutations wa...
Topics
- 1,2-Dimethylhydrazine
- Animals
- Cell Transformation, Neoplastic
- Colonic Neoplasms
- Genes, APC
- Genes, ras
- Immunoenzyme Techniques
- Male
- Mucins
- Mutagens
- Mutation
- Peptides
- Precancerous Conditions
- Rats
- Rats, Inbred F344
- Trefoil Factor-2