Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.

Journal of cancer research and clinical oncology - 1 Jun 2003

Sakai Hiroki, Tsukamoto Tetsuya, Yamamoto Masami, Shirai Norimitsu, Iidaka Takeshi, Hirata Akihiro, Yanai Tokuma, Masegi Toshiaki, Donehower Lawrence A, Tatematsu Masae

Abstract excerpt

PURPOSE: The susceptibility of male p53 nullizygote (-/-), heterozygote (+/-), and wild-type (+/+) mice to 1,2-dimethylhydrazine (DMH) induction of colon carcinogenesis was investigated. METHODS: In a preliminary short-term experiment, male mice of three genotypes were given s.c. of 20 mg/kg DMH once weekly for 5 weeks. In a medium-term experiment, mice were given weekly s.c. of DMH for 15 weeks. In a long-term...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to Carcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Colorectal Neoplasms

Share to Disease Models, Animal

Share to Genes, p53

Share to Injections, Subcutaneous

Share to Mice, Knockout

Source

Identifiers

PMID: 12743811
DOI: 10.1007/s00432-003-0443-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.PMID 12743811Read ↗

p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.Semantic proximity Read ↗

Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice.Semantic proximity Read ↗

p53 transgenic mice are highly susceptible to 1, 2-dimethylhydrazine-induced uterine sarcomas.Semantic proximity Read ↗

1,2-Dimethylhydrazine-induced colon carcinoma and lymphoma in msh2(-/-) mice.Semantic proximity Read ↗

The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer.Semantic proximity Read ↗

Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.Semantic proximity Read ↗

Gene expression profile and genomic alterations in colonic tumours induced by 1,2-dimethylhydrazine (DMH) in ratsSemantic proximity Read ↗

A locus that influences susceptibility to 1, 2-dimethylhydrazine-induced colon tumors maps to the distal end of mouse chromosome 3.Semantic proximity Read ↗

No allelic loss at the p53 locus in 1,2-dimethylhydrazine-induced mouse colon tumours: PCR-SSCP analysis with sequence-tagged microsatellite site primers.Semantic proximity Read ↗

High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.Semantic proximity Read ↗

Frequent mutation of Apc gene in rat colon tumors and mucin-depleted foci, preneoplastic lesions in experimental colon carcinogenesis.Semantic proximity Read ↗

Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.