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Article

Apc-driven colon carcinogenesis in Pirc rat is strongly reduced by polyethylene glycol.

International journal of cancer - 1 Nov 2015

Femia Angelo Pietro, Becherucci Caterina, Crucitta Stefania, Caderni Giovanna

Abstract excerpt

Polyethylene glycol (PEG) is one of the most powerful agents in reducing chemically induced carcinogenesis in rat colon. However, contrasting results in Min mice dampened the enthusiasm on this potentially strong and virtually safe, cancer chemopreventing agent. Pirc (F344/NTac-Apc (am1137) ) rats carrying a germline heterozygous mutation in the Apc gene, spontaneously develop multiple tumours in the colon thus...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25912754
DOI: 10.1002/ijc.29581

Genes

FAP

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