Article
Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families.
Genetic epidemiology - 1 Apr 2001
Mathias R A, Freidhoff L R, Blumenthal M N, Meyers D A, Lester L, King R, Xu J F, Solway J, Barnes K C, Pierce J, Stine O C, Togias A, Oetting W, Marshik P L, Hetmanski J B, Huang S K, Ehrlich E, Dunston G M, Malveaux F, Banks-Schlegel S, Cox N J, Bleecker E, Ober C, Beaty T H, Rich S S
Abstract excerpt
Variance components models were used to analyze total IgE levels in families ascertained though the Collaborative Study of the Genetics of Asthma (CSGA) using a genome-wide array of polymorphic markers. While IgE levels are known to be associated with clinical asthma and recognized to be under strong genetic control (here the heritability was estimated at 44-60% in the three racial groups), specific genes...
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