A genome-wide search for quantitative trait loci underlying asthma.

doi:10.1038/383247a0

Article

A genome-wide search for quantitative trait loci underlying asthma.

Nature - 19 Sept 1996

Daniels S E, Bhattacharrya S, James A, Leaves N I, Young A, Hill M R, Faux J A, Ryan G F, le Söuef P N, Lathrop G M, Musk A W, Cookson W O

Abstract excerpt

Asthma now affects one child in seven in the United Kingdom. Most cases (95%) of childhood asthma are associated with atopy, the immunoglobulin E (IgE)-mediated familial syndrome of allergic asthma, eczema and rhinitis. Segregation analysis has consistently suggested the presence of major genes i...

Topics

Adolescent
Asthma
Child
Eosinophils
Genetic Linkage
Genetic Markers
Genome, Human
Genotype
Humans
Immunoglobulin E
Leukocyte Count
Monte Carlo Method
Phenotype
Radioallergosorbent Test
Skin Tests

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