Article
A genome-wide search for quantitative trait loci underlying asthma.
Nature - 19 Sept 1996
Daniels S E, Bhattacharrya S, James A, Leaves N I, Young A, Hill M R, Faux J A, Ryan G F, le Söuef P N, Lathrop G M, Musk A W, Cookson W O
Abstract excerpt
Asthma now affects one child in seven in the United Kingdom. Most cases (95%) of childhood asthma are associated with atopy, the immunoglobulin E (IgE)-mediated familial syndrome of allergic asthma, eczema and rhinitis. Segregation analysis has consistently suggested the presence of major genes influencing atopy and IgE levels, with the expectation that these genes may be identified by positional cloning or the...
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