A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma.

doi:10.1007/s00439-003-1030-5

Article

A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma.

Human genetics - 1 Jan 2004

Blumenthal Malcolm N, Langefeld Carl D, Beaty Terri H, Bleecker Eugene R, Ober Carole, Lester Lucille, Lange Ethan, Barnes Kathleen C, Wolf Raoul, King Richard A, Solway Julian, Oetting William, Meyers Deborah A, Rich Stephen S

Abstract excerpt

Atopy is an IgE-mediated condition known to aggregate in families and is a major risk factor for asthma. As part of the Collaborative Study on the Genetics of Asthma (CSGA), a genome-wide scan for atopy, defined by skin sensitivity to one or more common environmental allergens, was conducted in 287 CSGA families (115 African American, 138 Caucasian and 34 Hispanic). Using a nonparametric genetic analysis...

Topics

Adolescent
Adult
Asthma
Black People
Child
Chromosome Mapping
Disease Susceptibility
Ethnicity
Female
Genome, Human

Genotype

Hispanic or Latino

Humans

Hypersensitivity, Immediate

Immunoglobulin E

Lod Score

Male

Models, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.