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Article

Evidence for a locus regulating total serum IgE levels mapping to chromosome 5.

Genomics - 15 Sept 1994

Meyers D A, Postma D S, Panhuysen C I, Xu J, Amelung P J, Levitt R C, Bleecker E R

Abstract excerpt

Genetics studies of total serum IgE levels were performed since high IgE levels correlate with clinical expression of allergy and asthma. Families ascertained through a parent with asthma were genotyped for markers on 5q where there are multiple candidate genes that may influence the control of IgE and inflammation. Evidence for linkage of the IgE phenotype to 5q was obtained by both sib-pair and lod score...

Topics

Adult
Asthma
Child
Chromosome Mapping
Chromosomes, Human, Pair 5
Female
Genes, Immunoglobulin
Genetic Linkage
Genetic Markers
Humans
Hypersensitivity
Immunoglobulin E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Netherlands

Phenotype

Source

Identifiers

PMID: 7835897
DOI: 10.1006/geno.1994.1524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7835897-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Related research

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Evidence for a locus regulating total serum IgE levels mapping to chromosome 5.PMID 7835897Read ↗

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