Article
Evidence for two unlinked loci regulating total serum IgE levels.
American journal of human genetics - 1 Aug 1995
Xu J, Levitt R C, Panhuysen C I, Postma D S, Taylor E W, Amelung P J, Holroyd K J, Bleecker E R, Meyers D A
Abstract excerpt
Studies investigating the genetic control of total serum IgE levels are of major importance in understanding basic pathophysiologic mechanisms in atopy and asthma, since IgE levels predict onset and correlate with the clinical expression of these disorders. Previous analysis of data from 92 families, ascertained through a parent with asthma, showed evidence for recessive inheritance of high IgE levels with...
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