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Article

Novel association suggests multiple independent QTLs within chromosome 5q21-33 region control variation in total humans IgE levels.

Genes and immunity - 1 Jun 2003

Ahmadi K R, Lanchbury J S, Reed P, Chiano M, Thompson D, Galley M, Line A, Lank E, Wong H J, Strachan D, Spector T D

Abstract excerpt

Asthma is a common, heterogeneous, complex disease accompanied by raised total and specific immunoglobulin-E (IgE) antibody levels. Despite numerous previous reports of linkage and association of asthma, atopy and serum IgE levels to genes within the 5q21-33 region, definitive, replicable results are still not available. We used the classical twin design to (i) estimate the relative contributions of genes and...

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PMID: 12761566
DOI: 10.1038/sj.gene.6363968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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