Article
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.
The Journal of allergy and clinical immunology - 1 Apr 2013
Levin Albert M, Mathias Rasika A, Huang Lili, Roth Lindsey A, Daley Denise, Myers Rachel A, Himes Blanca E, Romieu Isabelle, Yang Mao, Eng Celeste, Park Julie E, Zoratti Karla, Gignoux Christopher R, Torgerson Dara G, Galanter Joshua M, Huntsman Scott, Nguyen Elizabeth A, Becker Allan B, Chan-Yeung Moira, Kozyrskyj Anita L, Kwok Pui-Yan, Gilliland Frank D, Gauderman W James, Bleecker Eugene R, Raby Benjamin A, Meyers Deborah A, London Stephanie J, Martinez Fernando D, Weiss Scott T, Burchard Esteban G, Nicolae Dan L, Ober Carole, Barnes Kathleen C, Williams L Keoki
Abstract excerpt
BACKGROUND: IgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE. OBJECTIVE: We sought to identify the genetic predictors of serum total IgE levels. METHODS: We used genome-wide association data from 4292 subjects (2469 African...
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