Article
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
The Journal of allergy and clinical immunology - 1 Mar 2012
Granada Mark, Wilk Jemma B, Tuzova Marina, Strachan David P, Weidinger Stephan, Albrecht Eva, Gieger Christian, Heinrich Joachim, Himes Blanca E, Hunninghake Gary M, Celedón Juan C, Weiss Scott T, Cruikshank William W, Farrer Lindsay A, Center David M, O'Connor George T
Abstract excerpt
BACKGROUND: Atopy and plasma IgE concentration are genetically complex traits, and the specific genetic risk factors that lead to IgE dysregulation and clinical atopy are an area of active investigation. OBJECTIVE: We sought to ascertain the genetic risk factors that lead to IgE dysregulation. METHODS: A genome-wide association study (GWAS) was performed in 6819 participants from the Framingham Heart Study (FHS)....
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