Article
Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule.
International journal of cancer - 15 Feb 2001
Lucas R, Montesano R, Pepper M S, Hafner M, Sablon E, Dunant Y, Grau G E, De Baetselier P, Männel D, Fransen L
Abstract excerpt
In this study, we characterised the anti-tumour as well as the pro-metastatic activities of TNF mutants deficient in their lectin-like activity.1619 We report that, despite reduced systemic toxicity as compared to wild-type (wt) mTNF, a (T104A) and a (T104A-E106A-E109A) mTNF mutant (triple mTNF) retained most of their necrotic and tumouristatic activities, as measured in a CFS-1 fibrosarcoma and a B16BL6 melanoma...
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