Article
Generation of a mouse tumor necrosis factor mutant with antiperitonitis and desensitization activities comparable to those of the wild type but with reduced systemic toxicity.
Infection and immunity - 1 Jun 1997
Lucas R, Echtenacher B, Sablon E, Juillard P, Magez S, Lou J, Donati Y, Bosman F, Van de Voorde A, Fransen L, Männel D N, Grau G E, de Baetselier P
Abstract excerpt
In this study, we investigated whether the recently identified lectin-like domain of tumor necrosis factor (TNF) is implicated in its biological activities on mammalian cells. To this end, a mouse TNF (mTNF) triple mutant, T104A-E106A-E109A mTNF (referred to hereafter as triple mTNF), lacking the...
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