Article
A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact.
Cell - 19 Oct 1990
Perez C, Albert I, DeFay K, Zachariades N, Gooding L, Kriegler M
Abstract excerpt
In addition to the induction of tumor regression, tumor necrosis factor (TNF) has been implicated as the causative agent in a number of pathologies, including cachexia, septic shock, rheumatoid arthritis, autoimmunity, and induction of HIV expression. We propose that this complex physiology might be manifest by different forms of TNF: the 17 kd secretory component, the 26 kd transmembrane form, or both. To...
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