Article
A nonsecretable cell surface mutant of tumor necrosis factor (TNF) kills by cell-to-cell contact.
Cell - 19 Oct 1990
Perez C, Albert I, DeFay K, Zachariades N, Gooding L, Kriegler M
Abstract excerpt
In addition to the induction of tumor regression, tumor necrosis factor (TNF) has been implicated as the causative agent in a number of pathologies, including cachexia, septic shock, rheumatoid arthritis, autoimmunity, and induction of HIV expression. We propose that this complex physiology might...
Topics
- Amino Acid Sequence
- Animals
- Cell Communication
- Cell Line
- Cell Survival
- Cell Transformation, Viral
- Mice
- Molecular Sequence Data
- Molecular Weight
- Mutagenesis, Site-Directed
- Oligonucleotide Probes
- Phenotype
- Plasmids
- Recombinant Proteins
- Restriction Mapping
- Transfection
- Tumor Necrosis Factor-alpha