Article
Dissociation of TNF-alpha cytotoxic and proinflammatory activities by p55 receptor- and p75 receptor-selective TNF-alpha mutants.
The EMBO journal - 15 Feb 1994
Barbara J A, Smith W B, Gamble J R, Van Ostade X, Vandenabeele P, Tavernier J, Fiers W, Vadas M A, Lopez A F
Abstract excerpt
Human tumour necrosis factor alpha (TNF-alpha) is a pleiotropic cytokine capable of killing mammalian tumour cells in vitro and in vivo, and of enhancing the proinflammatory activity of leucocytes and endothelium, the latter effects limiting its usage as an antitumour agent in humans. Using TNF-alpha mutants with a selective capacity to bind to the TNF p55 receptor (TNFR55) or to the p75 receptor (TNFR75) we show...
Topics
- Binding Sites
- Cell Adhesion Molecules
- Cell Survival
- Cells, Cultured
- E-Selectin
- Endothelium, Vascular
- Granulocyte-Macrophage Colony-Stimulating Factor
- Humans
- Inflammation
- Interleukin-8