Article
Biological activity of mutants of human tumour necrosis factor-alpha.
Immunology - 1 Jul 1992
Kircheis R, Milleck J, Korobko V G, Shingarova L N, Behnke D, Schmidt H E
Abstract excerpt
Point mutations in different regions of the tumour necrosis factor-alpha (TNF-alpha) molecule influence anti-tumour cytotoxic/cytostatic activities as well as haemorrhagic tumour necrosis, tumour regression and lethal toxicity in mice. Mutations in the C-terminal region in positions 150 and 155 m...
Topics
- Amino Acid Sequence
- Animals
- Binding, Competitive
- Breast Neoplasms
- Cell Division
- Cell Line
- Cytotoxicity, Immunologic
- Fibroblasts
- Humans
- Lethal Dose 50
- Leukemia, Monocytic, Acute
- Leukemia, Promyelocytic, Acute
- Mice
- Molecular Sequence Data
- Mutation
- Neoplasms
- Sequence Homology, Nucleic Acid
- Tumor Cells, Cultured