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Article

Biological activity of mutants of human tumour necrosis factor-alpha.

Immunology - 1 Jul 1992

Kircheis R, Milleck J, Korobko V G, Shingarova L N, Behnke D, Schmidt H E

Abstract excerpt

Point mutations in different regions of the tumour necrosis factor-alpha (TNF-alpha) molecule influence anti-tumour cytotoxic/cytostatic activities as well as haemorrhagic tumour necrosis, tumour regression and lethal toxicity in mice. Mutations in the C-terminal region in positions 150 and 155 markedly decrease cytotoxicity for murine L929 fibroblasts and human MCF7 mammary carcinoma cells. Competitive binding...

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Identifiers

PMID: 1526652
PMCID: PMC1421674

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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