Article
A YIGSR-containing novel mutein without the detrimental effect of human TNF-alpha of enhancing experimental pulmonary metastasis.
Clinical & experimental metastasis - 1 Jul 1992
Miyata K, Kato M, Shikama H, Nishimura K, Sakae N, Kawagoe K, Nishikawa T, Kuroda K, Yamaguchi K, Aoyama Y
Abstract excerpt
The injection of B16F10 melanoma cells with recombinant human tumor necrosis factor alpha (TNF-alpha) into the tail vein of C57BL/6 mice resulted in 2- to 25-fold more metastatic foci in the lungs than the injection of tumor cells alone. Clearly, TNF-alpha significantly enhanced experimental tumo...
Topics
- Amino Acid Sequence
- Animals
- Cell Adhesion
- Humans
- Lung Neoplasms
- Melanoma, Experimental
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Neoplasm Transplantation
- Peptides
- Tumor Cells, Cultured
- Tumor Necrosis Factor-alpha