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Article

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo.

Cytotherapy - 1 Jan 2006

Yan Z, Zhao N, Wang Z, Li B, Bao C, Shi J, Han W, Zhang Y

Abstract excerpt

BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine that has cytotoxic, cytostatic and immunomodulatory effects on malignant tumors. However, clinical trials have revealed high systemic toxicity and this has hampered its utilization as an anti-cancer agent. In this study, a human TNF-alpha mutant was created and tested for its anti-tumor effects. METHODS: The TNF mutant (recombinant...

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Source

Identifiers

PMID: 16923618
DOI: 10.1080/14653240600845278

Genes

TNF
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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