Article
Mapping the lectin-like activity of tumor necrosis factor.
Science (New York, N.Y.) - 11 Feb 1994
Lucas R, Magez S, De Leys R, Fransen L, Scheerlinck J P, Rampelberg M, Sablon E, De Baetselier P
Abstract excerpt
Tumor necrosis factor (TNF), but not lymphotoxin (LT), is directly trypanolytic for salivarian trypanosomes. This activity was not blocked by soluble 55-kilodalton and 75-kilodalton TNF receptors, but was potently inhibited by N,N'-diacetylchitobiose, an oligosaccharide that binds TNF. Comparative sequence analysis of TNF and LT localized the trypanocidal region, and synthetic peptides were trypanolytic. TNF...
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