Article
Mapping the lectin-like activity of tumor necrosis factor.
Science (New York, N.Y.) - 11 Feb 1994
Lucas R, Magez S, De Leys R, Fransen L, Scheerlinck J P, Rampelberg M, Sablon E, De Baetselier P
Abstract excerpt
Tumor necrosis factor (TNF), but not lymphotoxin (LT), is directly trypanolytic for salivarian trypanosomes. This activity was not blocked by soluble 55-kilodalton and 75-kilodalton TNF receptors, but was potently inhibited by N,N'-diacetylchitobiose, an oligosaccharide that binds TNF. Comparativ...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Disaccharides
- Glucans
- L Cells
- Lectins
- Lymphotoxin-alpha
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Receptors, Tumor Necrosis Factor
- Trypanosoma brucei brucei
- Tumor Necrosis Factor-alpha