Article
Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats.
Alcoholism, clinical and experimental research - 1 Jan 2001
Hyytiä P, Kiianmaa K
Abstract excerpt
BACKGROUND: Both mu- and delta-opioid receptors have been implicated in the reinforcing actions of ethanol. However, selective opioid receptor antagonists have not altered ethanol intake in all rodent strains consistently, which suggests that genotype may modulate their suppressive effects. Therefore, we tested the effects of the selective mu-antagonist D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) and the...
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