Article
GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 2001
June H L, Harvey S C, Foster K L, McKay P F, Cummings R, Garcia M, Mason D, Grey C, McCane S, Williams L S, Johnson T B, He X, Rock S, Cook J M
Abstract excerpt
GABA receptors within the mesolimbic circuitry have been proposed to play a role in regulating alcohol-seeking behaviors in the alcohol-preferring (P) rat. However, the precise GABA(A) receptor subunit(s) mediating the reinforcing properties of EtOH remains unknown. We examined the capacity of intrahippocampal infusions of an alpha5 subunit-selective ( approximately 75-fold) benzodiazepine (BDZ) inverse agonist...
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