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Article

Delta-opioid receptor antagonism leads to excessive ethanol consumption in mice with enhanced activity of the endogenous opioid system.

Neuropharmacology - 15 May 2017

Poznanski Piotr, Lesniak Anna, Korostynski Michal, Szklarczyk Klaudia, Lazarczyk Marzena, Religa Piotr, Bujalska-Zadrozny Magdalena, Sadowski Bogdan, Sacharczuk Mariusz

Abstract excerpt

The opioid system modulates the central reinforcing effects of ethanol and participates in the etiology of addiction. However, the pharmacotherapy of ethanol dependence targeted on the opioid system is little effective and varies due to individual patients' sensitivity. In the present study, we used two mouse lines with high (HA) and low (LA) activity of the endogenous opioid system to analyze the effect of...

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PMID: 28322978
DOI: 10.1016/j.neuropharm.2017.03.016

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Delta-opioid receptor antagonism leads to excessive ethanol consumption in mice with enhanced activity of the endogenous opioid system.PMID 28322978Read ↗

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