Article
The opioid receptor antagonist nalmefene reduces responding maintained by ethanol presentation: preclinical studies in ethanol-preferring and outbred Wistar rats.
Alcoholism, clinical and experimental research - 1 Dec 1998
June H L, Grey C, Warren-Reese C, Durr L F, Ricks-Cord A, Johnson A, McCane S, Williams L S, Mason D, Cummings R, Lawrence A
Abstract excerpt
Nalmefene, the 6-methylene derivative of naltrexone, was examined after subcutaneous (s.c.) (0.0001 to 8.0 mg/kg) and oral (10 to 80.0 mg/kg) administration in ethanol (EtOH)-preferring rats whose responding (i.e., lever pressing) was maintained by the presentation of EtOH. Naltrexone (0.01 to 40...
Topics
- Alcohol Drinking
- Alcoholism
- Animals
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Female
- Genotype
- Male
- Motivation
- Naltrexone
- Narcotic Antagonists
- Rats
- Rats, Inbred Strains