Article
Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats.
Biological psychiatry - 15 Apr 2013
Schank Jesse R, Tapocik Jenica D, Barbier Estelle, Damadzic Ruslan, Eskay Robert L, Sun Hui, Rowe Kelly E, King Courtney E, Yao Mengdi, Flanigan Meghan E, Solomon Matthew G, Karlsson Camilla, Cheng Kejun, Rice Kenner C, Heilig Markus
Abstract excerpt
BACKGROUND: Genetic deletion or antagonism of the neurokinin 1 receptor (NK1R) decreases alcohol intake, alcohol reward, and stress-induced alcohol relapse in rodents, while TACR1 variation is associated with alcoholism in humans. METHODS: We used L822429, a specific antagonist with high affinity for the rat NK1R, and examined whether sensitivity to NK1R blockade is altered in alcohol-preferring (P) rats. Operant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.