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Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2003

Chackerian Alissa A, Behar Samuel M

Abstract excerpt

Inbred strains of mice exhibit varied patterns of susceptibility following infection with virulent Mycobacterium tuberculosis. Susceptible mice have progressive fulminate disease resulting in their premature death; in contrast, resistant mice are able to control bacterial replication, limit lung injury and survive longer. The use of these mouse strains in experimental infection has allowed the identification of...

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Identifiers

PMID: 12972341
DOI: 10.1016/s1472-9792(03)00017-9

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