Article
Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 2000
Kramnik I, Dietrich W F, Demant P, Bloom B R
Abstract excerpt
Over 2 billion people are estimated to be infected with virulent Mycobacterium tuberculosis, yet fewer than 10% progress to clinical tuberculosis within their lifetime. Twin studies and variations in the outcome of tuberculosis infection after exposure to similar environmental risks suggest genetic heterogeneity among individuals in their susceptibility to disease. In a mouse model of tuberculosis, we have...
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