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Article

Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers

7 Jun 2000

Abstract excerpt

BACKGROUND: PTEN tumor suppressor gene mutations are the most frequent genetic lesions in endometrial adenocarcinomas of the endometrioid subtype. Testing the hypothesis that altered PTEN function precedes the appearance of endometrial adenocarcinoma has been difficult, however, partly because of uncertainties in precancer diagnosis. METHODS: Two series of endometrial cancer and precancer (endometrial...

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PMID: 10841828
DOI: 10.1093/jnci/92.11.924

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