Article
Clonal analysis and mutations in the PTEN and the K-ras genes in endometrial hyperplasia.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Dec 2002
Sun Hongbo, Enomoto Takayuki, Shroyer Kenneth R, Ozaki Keiichiro, Fujita Masami, Ueda Yutaka, Nakashima Ryuichi, Kuragaki Chie, Ueda Gaiko, Murata Yuji
Abstract excerpt
The patterns of X chromosome inactivation and mutations of PTEN and K-ras were evaluated in cases of endometrial hyperplasia to determine the presence of potentially premalignant neoplastic versus polyclonal benign cell populations. Endometrial glandular epithelial cells were collected by laser capture microdissection, and genomic DNAs were extracted. Following treatment with the methylation sensitive restriction...
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